Mechanics of biological systems :introduction to mechanobiology and experimental techniques /

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"Version: 20191101"--Title page verso."A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.Includes bibliographical references.1. Force, stress, and mechanical properties in biological systems -- 1.1. Overview2. Mechanics primers and theoretical models for biomaterial characterization -- 2.1. Overview -- 2.2. Force -- 2.3. Stress -- 2.4. Parameters for mechanical properties -- 2.5. Basic rules of mechanics -- 2.6. Hyperelastic models -- 2.7. Viscoelastic model -- 2.8. The poroelastic model3. Important forces at the molecular level and how to measure them -- 3.1. Overview -- 3.2. Force generated by motor proteins -- 3.3. Forces generated by actin polymerization -- 3.4. Forces generated by microtubule polymerization -- 3.5. Force required for breaking intermolecular bonds -- 3.6. Torque -- 3.7. Supercoiling in DNA -- 3.8. Rotational energy during ATP synthesis -- 3.9. Force and torque measurement techniques at the molecular level4. Important forces at the cellular level and how to measure them -- 4.1. Overview -- 4.2. Force generation, transmission, and sensing at the cellular level -- 4.3. Cancer metastasis -- 4.4. Mechanosensitive gene expression -- 4.5. Mechanical properties of the cell -- 4.6. Force and mechanical property measurements5. Important forces at the tissue level and how to measure them -- 5.1. Overview -- 5.2. Principles of force generation and coordination at the tissue level -- 5.3. Mechanoresponsive processes at the tissue level -- 5.4. Force, stress, and mechanical property measurement techniques at the tissue level.This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales--molecular, cellular, and tissue levels--sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Yun Chen is an assistant professor in the Department of Mechanical Engineering, at Johns Hopkins University, MD. She is specialized in developing multi-scale, multi-modal imaging tools to study how mechanics integrates with other biophysical and biochemical factors to sustain normal physiology or to cause pathology. Seungman Park is currently a Postdoctoral Associate at Johns Hopkins University, MD. Dr. Park Received his Ph.D. degree in Mechanical Engineering from Purdue University, IN, in 2014. His research area is tissue engineering, cell mechanics, and mechanobiology. Dr. Park is a member of American Heart Association, American Physical Society, American Society of Cell Biology and Biophysical Society. He is also the awardee of Maryland Stem Cell Research Fund Fellowship.Title from PDF title page (viewed on December 9, 2019).

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9781643273921

Classification

571.43

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Mensuration & systems of measurement.
SCIENCE / Weights & Measures.
Biomechanics.

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Statement of Responsibility

Seungman Park and Yun Chen.

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