Cold atmospheric plasma-based cancer therapy /

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"Version: 20230901"--Title page verso.Revised edition of: Cold plasma cancer therapy.Includes bibliographical references.1. Introduction to non-thermal plasma physics -- 1.1. Plasma -- 1.2. Plasma quasi-neutrality -- 1.3. Plasma oscillations -- 1.4. Particle collisions -- 1.5. Plasma types -- 1.6. Cold atmospheric plasmas (CAP) -- 1.7. CAP in plasma therapy2. Cold atmospheric plasma generators -- 2.1. Ionization -- 2.2. Cold atmospheric plasma3. Diagnostics and modeling of cold atmospheric plasmas -- 3.1. General overview of CAP diagnostics -- 3.2. Numerical simulation and modeling4. Chemically based cold atmospheric plasma treatment -- 4.1. Anti-cancer demonstration in vitro -- 4.2. Two treatment approaches -- 4.3. Anti-cancer mechanism5. Cold atmospheric plasma-activated solutions -- 5.1. Indirect CAP treatment -- 5.2. Effective components in PAS -- 5.3. Instability in storage6. Physics based cold atmospheric plasma therapy -- 6.1. Limitation of chemically-based treatment -- 6.2. Revealing physical effect -- 6.3. Necrotic cell death -- 6.4. Bubbling and osmotic pressure -- 6.5. Anti-cancer physical factors in CAP -- 6.6. Modulating physical effects -- 6.7. Trans barrier capability -- 6.8. Physical versus chemical treatment7. Selective anti-cancer performance -- 7.1. Selective anti-cancer effect -- 7.2. Selective anti-cancer mechanism -- 7.3. H2O2 channels : aquaporins (AQP) -- 7.4. Antioxidant system -- 7.5. Transient membrane pores -- 7.6. Singlet oxygen -- 7.7. Genomic repairing system -- 7.8. Novel selectivity concepts -- 7.9. Summary8. Animal studies and immune responses -- 8.1. Cutaneous CAP treatment -- 8.2. Intracranial models -- 8.3. Abscopal phenomena -- 8.4. Sensitization of tumor to drugs -- 8.5. Transdermal anti-tumor mechanism -- 8.6. Thermal effect -- 8.7. Immune responses9. Clinical perspectives -- 9.1. Clinical studies -- 9.2. Outlook10. Physics and technology of the adaptive plasma therapy -- 10.1. Plasma self-organization phenomena -- 10.2. Adaptive plasma devices -- 10.3. MPC-based adaptive plasma platform -- 10.4. Electrochemical response of cells to plasma : real-time impedance measurements -- 10.5. Adaptive plasma treatment based on machine learning technologies -- 10.6. Intelligent plasma based on self-organization patterns.With the unique chemical and physical properties of cold atmospheric plasmas enabling their recent applications in biomedicine, plasma medicine has established itself as a new scientific field, combining plasma physics, engineering, medicine, and bioengineering. This book provides a comprehensive introduction to the fundamentals of the non-thermal plasmas and plasma devices used in plasma medicine. Several chapters are devoted to the analysis of the mechanisms of plasma interaction with cancer and normal cells, including a description of the mechanism of plasma selectivity. As a revised and significantly expanded second edition, this text includes a detailed description of non-invasive modality, new in vivo work and adaptive plasma written by experts in these areas. This reference text also provides an up-to-date description of the field, the primary challenges and future directions. Part of IOP Series in Plasma Physics.Researchers in low temperature plasmas and cancer therapy.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Michael Keidar is an A. James Clark Professor of Engineering. His research concerns plasma physics and engineering with application in plasma medicine, advanced spacecraft propulsion, and plasma-based nanotechnology. He received the 2017 Davidson award in plasma physics. In 2016, he received the AIAA Engineer of the Year award for his work on micropropulsion, which resulted in the successful launch of a nanosatellite with thrusters developed by his laboratory. Dayun Yan is a postdoctoral researcher at George Washington University. His current research focuses on several core problems in plasma sources and plasma medicine. By August 2022, Dayun had published ~60 papers in peer-reviewed journals. He wrote the first edition of Cold Plasma Cancer Therapy. He has been a guest editor of three journals (Applied Sciences, Pharmaceutics, and Biomedicines) and a peer-reviewer for 80+ journals. Li Lin is a postdoctoral researcher at George Washington University. His research interests are low-temperature plasma physics and chemistry, plasma simulation, plasma and biomedical diagnostics, microwave technologies, and machine learning. Li is also an editorial board member of Scientific Reports, an editorial board member of Medical Science, a topic editor of Catalysts, a reviewer board member of Symmetry, and a member of IEEE and APS. Li has published over 40 journal article publications.Title from PDF title page (viewed on October 3, 2023).

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Series Title

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Call Number

-

Publisher

: .,

Collation

1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9780750355377

Classification

616.99406

Content Type

-

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-

Carrier Type

-

Edition

Second edition.

Subject(s)

SCIENCE / Physics / Atomic & Molecular.
Plasma physics.
Cancer
Neoplasms
Low temperature plasmas
Plasma Gases

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Statement of Responsibility

Michael Keidar, Dayun Yan, Li Lin.

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