Biopolymer networks :design, dynamics and discovery /

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"Version: 20240801"--Title page verso.Includes bibliographical references.part I. Let's get started. 1. Introduction to biopolymers and their networks -- 1.1. Polymers 101 -- 1.2. Biopolymer basics -- 1.3. Biopolymer networks in biology -- 1.4. Biopolymer networks in physics and engineering -- 1.5. What next?part II. Making sense and measuring. 2. Polymer physics for everyone -- 2.1. The beauty of polymer physics -- 2.2. Polymer flexibility -- 2.3. Single polymer conformations -- 2.4. Single polymer dynamics -- 2.5. Beyond the standard tube model -- 2.6. Rheology -- 2.7. Semiflexible polymers -- 2.8. Rigid rod polymers -- 2.9. Crosslinked polymer networks -- 2.10. Nonlinear viscoelasticity -- 2.11. To be continued ...3. Measuring mechanics, dynamics, and structure -- 3.1. Direct imaging of biopolymers -- 3.2. Direct measurements of force, stress, and dynamics -- 3.3. What's next4. Analysis methods, algorithms, and deliverables -- 4.1. Single-molecule center-of-mass tracking -- 4.2. Single-particle tracking (SPT) -- 4.3. Particle-image velocimetry (PIV) -- 4.4. Differential dynamic microscopy (DDM) -- 4.5. Spatial image autocorrelation -- 4.6. Advanced techniques and further reading5. Biopolymer network design, dynamics, and mechanics -- 5.1. DNA solutions : from dilute to highly entangled -- 5.2. Entangled and crosslinked actin networks -- 5.3. Entangled and crosslinked networks of microtubules -- 5.4. Intermediate filament (IF) networks -- 5.5. Canonical building blocks for complex biopolymer networkspart III. Beyond the basics--novel and complex networks. 6. Networks of topologically-novel biopolymers -- 6.1. Relaxed circular (ring) biopolymers -- 6.2. Supercoiled circular biopolymers -- 6.3. Concatenated ring biopolymers -- 6.4. Branched biopolymers -- 6.5. Building in complexity7. Biopolymer composites, blends, and crowding -- 7.1. Biopolymer blends -- 7.2. Biopolymer composites -- 7.3. Considerations and outlookpart IV. Spatiotemporal heterogeneity : from active matter to coacervates. 8. Active, responsive, and reconfigurable networks -- 8.1. Motor-driven cytoskeleton networks -- 8.2. Chemically-triggered biopolymer networks -- 8.3. Non-equilibrium DNA networks -- 8.4. Considerations and outlook9. Self-assembly and phase separation -- 9.1. Beyond local heterogeneity -- 9.2. Introduction to liquid-liquid phase separation (LLPS) -- 9.3. Crowding and liquid-liquid phase separation -- 9.4. Complex coacervates -- 9.5. LLPS of intrinsically disordered proteins -- 9.6. LLPS of nucleic acids -- 9.7. Structurally heterogeneous condensates -- 9.8. Active and dynamic liquid-liquid phase separation -- 9.9. Viscoelastic phase separation (VPS) -- 9.10. Considerations and outlookpart V. What now? 10. Past, present, and future : perspectives from the community -- 10.1. What we have learned -- 10.2. What we are still learning -- 10.3. Who 'we' are and what we think -- 10.4. What are the big open questions in the field of biopolymer networks? -- 10.5. What is needed in the research community to make advances in the field? -- 10.6. What is a 'must-read' for anyone interested in learning more about the field?Full-text restricted to subscribers or individual document purchasers.This reference text provides a broad overview of biopolymer networks written for an interdisciplinary audience of cellular and molecular biologists, soft matter and polymer physicists, materials scientists, and chemical engineers. It opens with an introduction to biopolymers and their networks, followed by an overview of important polymer physics theories and concepts, experimental tools to measure network properties, and computational analysis techniques to characterize and interpret data. The book follows with a description of model biopolymer networks--from design to rheology--before embarking on a discussion of novel network designs and their emergent physical properties, including topologically-novel polymers, composites, active matter, and liquid-liquid phase separation. It closes with a community-led perspective on key open questions and grand challenges, and how we may come together to advance understanding of biopolymer networks and their utility in diverse applications. Part of Biophysical Society-IOP series.This book will be a must read for researchers, academics (graduate students, postdocs, professors, research scientists, etc) and industry professionals in the fields of biophysics, soft and active matter, polymer physics, cellular biology, materials science, physical chemistry, and biomaterials engineering. The text will be written with this interdisciplinary audience in mind and will be the go-to resource for both seasoned researchers and those looking to enter the field. This text will also be accessible to undergraduates with upper division physics or biophysics training and could be used in graduate level courses in physics, biophysics, bioengineering and materials science programs.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Rae M. Robertson-Anderson is Professor of Physics and Biophysics and Associate Provost for Engaged Scholarship at the University of San Diego, where she has established an internationally recognized research program to elucidate macromolecular dynamics and microscale mechanics of bio-inspired soft and active matter systems. Robertson-Anderson is a leading expert in the design of novel microrheology methods and complex biopolymer composites to address critical questions in soft matter physics and cell biology. She is equally passionate about promoting and advancing undergraduate research and education, and building community among diverse scientists and with the general public. Robertson-Anderson has been awarded over $5M in grants to support her research, and her 74 publications feature 85 undergraduate co-authors.Title from PDF title page (viewed on September 3, 2024).

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Publisher

: .,

Collation

1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9780750350372

Classification

572.33

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-

Edition

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Subject(s)

Pre-clinical medicine - basic sciences.
Biopolymers.
Polymer networks.
MEDICAL / Biotechnology.

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Rae M. Robertson-Anderson.

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