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Physics of cancer.

Mierke, Claudia Tanja, - Personal Name; Institute of Physics (Great Britain), - Personal Name;

"Version: 20250501"--Title page verso.Includes bibliographical references.1. Matrix-modification by cells : exosomes and cancer -- 1.1. Summary -- 1.2. Introduction to the role of exosomes in cancer -- 1.3. Biogenesis of EVs -- 1.4. Cargo and biological make-up of EVs, such as exosomes -- 1.5. Cargo-centered view on the biogenesis of the exosomes and ectosomes -- 1.6. Regulation of cargo based on the cellular state -- 1.7. Cellular functions of exosomes in immune response -- 1.8. Cellular function of exosomes in cancer -- 1.9. Interplay between integrins and exosomes -- 1.10. Exosomes can serve as biomarkers for cancer, regenerative reservoir and vaccine cargo-systems -- 1.11. Conclusions and future directions2. Endosomes and receptor endocytic routes in cancer -- 2.1. Summary -- 2.2. Introduction to endosomes in cancer -- 2.3. Endosomes and the process of endocytosis -- 2.4. Generation of endosomes and their maturation -- 2.5. Lysosomes and creation of an endolysosome -- 2.6. Biogenesis of lysosomes -- 2.7. Biogenesis of endosomes during cancer development -- 2.8. Function of endosomes in signal transduction and cell fate regulation -- 2.9. Relationship between endocytosis and autophagy -- 2.10. Biogenesis of lysosomes during the development of cancer -- 2.11. Lysosomal cathepsins and their action during carcinogenesis -- 2.12. Lysosomal cathepsins function in apoptosis of cancer cells -- 2.13. Endocytic routes and cancer metastasis -- 2.14. Downstream endosomal transport -- 2.15. Integrin and ECM transportation during cancer metastasis -- 2.16. The sorting process of endosomes requires molecular motors and specific adaptor proteins -- 2.17. Metastasis and endocytosis suppressors -- 2.18. Transfer of invasive capacities by highly to lowly invasive cancer cells -- 2.19. Malfunction of recycling via endosomes in cancer -- 2.20. Interplay between autophagy inhibitory agents and endosome-based secretory routes : a challenge for autophagy-directed therapy of solid cancers -- 2.21. Conclusions and future directions3. The two faces of mast cells in cancer from a mechanobiological perspective -- 3.1. Summary -- 3.2. Introduction the interaction of cancer cells and MCs -- 3.3. Origin, location and function of MCs -- 3.4. Phenotype heterogeneity via polarization of MCs : tissue-specific phenotype of MCs -- 3.5. Crosstalk between MCs and the TME -- 3.6. Effect of mechanical cues, such as stiffness, on MCs in cancer -- 3.7. Two ways of MC activation -- 3.8. Effect of mechanical cues, like stiffness, on MC infiltration of solid tumors and TMEs -- 3.9. Communication between MCs and cancer cells in solid tumors -- 3.10. Pro-tumoral effects of MCs -- 3.11. Anti-tumoral effects of MCs -- 3.12. Conclusions and future perspective4. Apoptosis and the two faces of autophagy in cancer on different time scales -- 4.1. Summary -- 4.2. Introduction to the process of autophagy in cancer -- 4.3. Apoptosis -- 4.4. Autophagy -- 4.5. Two facets of autophagy -- 4.6. Impact on autophagy on cancer treatments -- 4.7. Function of autophagy in cancer treatment -- 4.8. Function of autophagy in stem cells -- 4.9. Cancer stem cells-a unique kind of stem cells -- 4.10. Autophagy functions in maintaining of stem cell characteristics -- 4.11. The importance of cancer stem cell autophagy -- 4.12. Phenomenon of mitophagy in cancer stem cells -- 4.13. NAD+ and nicotinamide phosphoribosyl transferase (NAMPT) can trigger autophagy of cancer stem cells -- 4.14. Impact of autophagy in cancer stem cell resistance to chemotherapy -- 4.15. Autophagy functions on the motility of cancer stem cells -- 4.16. Relationship between autophagy, decrease in calories and cancer -- 4.17. Conclusions and future directions5. Mechanobiological aspects of autophagy in cancer and various subtypes of selective autophagy -- 5.1. Summary -- 5.2. Introduction to the coupling of autophagy and mechanical stress -- 5.3. The cytoskeleton controls cell mechanical properties -- 5.4. Connection of mechanics and autophagy -- 5.5. The autolysosome -- 5.6. Interplay between cellular mechanics and autophagy -- 5.7. Mechanics of autophagy in the malignant progression of cancer -- 5.8. Mechanobiology of autophagy in cancer therapy and prevention of chemoresistance -- 5.9. Short classification of the autophagy process in its major subgroups -- 5.10. Mitophagy -- 5.11. Lysophagy -- 5.12. Aggrephagy -- 5.13. Xenophagy -- 5.14. ER-phagy -- 5.15. Pexophagy -- 5.16. Ribophagy -- 5.17. Golgiphagy -- 5.18. Selective autophagy linked to cellular processes or molecules -- 5.19. Conclusion and future directions6. Cancer as a mechanobiological disease : targeting the mechanism of mechanical plasticity and dynamical mechanoregulation -- 6.1. Summary -- 6.2. Introduction to the mechanobiology of cancer -- 6.3. The tumor mechanical microenvironment is subject to dynamic changes -- 6.4. The stiffness of the substrate impacts carcinogenesis -- 6.5. Several mechanical forces contribute to cancer advancement -- 6.6. Are tumors made up of soft cancer cells that promote the malignant progression of cancers? -- 6.7. Dynamical mechanoregulation of cancer metastasis -- 6.8. Possible connection between physical microenvironmental stresses and increased aggressiveness of metastasizing cancer cells -- 6.9. Stiffer prostate cancer cells are aggressive and metastatic -- 6.10. Conclusions and future directions7. The dynamic and adaptive mechanical signature of cancer cells and their molecular biological features regulate their metastatic journey -- 7.1. Summary -- 7.2. Single-cell fluidic force spectroscopy unveils dynamic mechanical signatures of malignant cancers in breast cancer -- 7.3. Combined mechanical and molecular biological probing of cancer cells -- 7.4. Dynamical adaption of cancer cells' mechanical characteristics : mechanoadaptive cancer cells metastasize -- 7.5. A cancer-intrinsic mechanism mechanically remodels cancer cells -- 7.6. Mechanical adaptability and its challenges are focused -- 7.7. Cellular cytoskeleton and stiffness are mechanical predictors of breast cancer organotropism -- 7.8. The mechanical characteristic of the route controls cancer metastasis -- 7.9. Conclusions and future directions.Full-text restricted to subscribers or individual document purchasers.Physics of Cancer, Volume 6 (Second edition) focuses on the topics of extracellular vesicular communication of cancer cells with their environment, such as matrix networks and neighbouring cells like immune and stromal cells, the role of autophagy in cancer and the dual function of mast cells in solid tumors in relation on immune regulation and mechanobiology. There is a rich history of the physical sciences contributing to cancer research and treatments, yet there is currently no book that covers all of the new techniques and developments in the field of the physics of cancer. The purpose of this book is to make these very relevant topics visible to the research field to ensure they receive more attention in the scientific community. Part of Biophysical Society-IOP series.Researchers, scientists and practitioners in the physics of cancer, biophysics.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumor microenvironment mechanics. She has published over 160 refereed journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 20 years, Claudia has taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.Title from PDF title page (viewed on June 2, 2025).

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Series Title: -
Call Number: -
Publisher: : .,
Collation: 1 online resource (various pagings) :illustrations (some color).
Language: English
ISBN/ISSN: 9780750340076
Classification: 616.994
Content Type: -
Media Type: -
Carrier Type: -
Edition: Second edition.
Subject(s): Biophysics.
SCIENCE / Life Sciences / Biophysics.
Cancer.
Pathology, Molecular.
Biomechanical Phenomena.
Cancer cells
Cell Transformation, Neoplastic.
Cell Physiological Phenomena.
Tumor Microenvironment.
Specific Detail Info: -
Statement of Responsibility: Claudia Tanja Mierke.

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