Physics of cancer.
"Version: 20231101"--Title page verso.Includes bibliographical references.1. Mechanosensing and the mechanotransduction of cells -- 1.1. An introduction to mechanosensation and mechanotransduction in living cells -- 1.2. Molecular mechanosensory behavior -- 1.3. The role of focal adhesion proteins -- 1.4. Interplay between mechanosensors -- 1.5. The interplay between focal adhesion proteins and cell-matrix receptors -- 1.6. The interplay between focal adhesion proteins and cell-cell adherence junctions -- 1.7. Force detection and transduction at adherens junctions -- 1.8. The transfer of mechanical forces at the cadherin-catenin complex -- 1.9. The role of the cytoskeleton -- 1.10. The role of the nucleus in sensing mechanical cues -- 1.11. Restrained mechanosensing in cancer -- 1.12. The regulation of gene expression in mechanotransduction in cancer cells -- 1.13. Alterations of the extracellular matrix environment in cancerous diseases -- 1.14. Conclusions and future perspectives2. Overview and discussion of biophysical techniques for the mechanical characterization of cell nuclei and cells -- 2.1. Introduction to biophysical techniques used for the mechanical characterization of the nuclei of living cells -- 2.2. Analysis of nuclear positioning in a living cell -- 2.3. Analysis of the nuclear mechanical characteristics -- 2.4. Components of the nuclear framework contribute to mechanosensing -- 2.5. Analyses of nuclear mechanics -- 2.6. Analysis of the cytoskeleton and cell cortex -- 2.7. A critical discussion of mechanical measurements of living cells -- 2.8. A discussion of the selection of a specific biophysical technique -- 2.9. Conclusions and future research3. Overview and discussion of biophysical techniques for the mechanical characterization of plasma membranes -- 3.1. A concise introduction to plasma membrane models -- 3.2. Giant plasma membrane vesicles serve as a model for the plasma membrane -- 3.3. Biophysical analysis of the plasma membrane of cells -- 3.4. The principles of the dynamics of the plasma membrane -- 3.5. Models and theories of the plasma membrane -- 3.6. The heat theory of the plasma membrane -- 3.7. The phenomenon of bioelectricity -- 3.8. The main findings in cancer research related to the plasma membrane -- 3.9. The prominent role of the bioelectrical code -- 3.10. Are aging and cancer opposite or the same sides of the coin in terms of pathology? -- 3.11. Bioelectric signal transmission within the mechanical microenvironment -- 3.12. Deciphering the direction of the flow of communication : separating the mechanical microenvironment from the bioelectrical signaling -- 3.13. Conclusions and future research4. A survey of biophysical techniques used for the mechanical characterization of cell spheroids, organoids, and tumoroids -- 4.1. An overview of multicellular culture models -- 4.2. Tissue explants -- 4.3. Cell cluster formation and cell aggregates -- 4.4. Cell spheroids -- 4.5. Organoids -- 4.6. The effect of organoid vascularization -- 4.7. Tumoroids -- 4.8. Mechanical measurements of cell clusters, spheroids, organoids, or tumoroids -- 4.9. The effects of cell sorting and invasion -- 4.10. A discussion of the advantages and disadvantages of cell aggregate mechanical analyses -- 4.11. Conclusions and future research.This is the fourth volume of the highly regarded Physics of Cancer (Second Edition) series, written with the aim of making very important topics in the physics of cancer visible to the research community. This fourth volume deals with mechanobiology using biophysical methods. The first chapter deals with mechanosensing and mechanotransduction on vastly different length scales. The second chapter discusses biophysical techniques for mechanical phenotype characterization of cells and nuclei. The third provides an overview of the mechanical phenotype of the plasma membrane. The fourth chapter contains the latest insights into the mechanical assessment of cell spheroids, organoids and tumoroids. The basic approach of this text is to present the latest promising findings to the scientific community, addressing scientists at all career stages. Part of Biophysical Society-IOP series.Scientists, researchers, graduate students, instructors in biophysics.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Claudia Tanja Mierke is Head of the Department of Biological Physics at the Peter Debye Institute for Soft Matter Physics at Leipzig University. Her primary research areas are cell biophysics and cell mechanics, adhesion, motility (invasion) in biomimetic matrices, cancer and inflammation, cancer metastasis and tumor microenvironment mechanics. She has published over 150 refereed journal articles, books and book chapters largely dealing with soft matter physics and the physics of cancer. Over the past 18 years, Claudia had taught courses in biophysics, soft matter physics, cell biology for physicists and cellular biophysics, to both undergraduate and graduate students.Title from PDF title page (viewed on December 1, 2023).
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1 online resource (various pagings) :illustrations (some color).
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English
- ISBN/ISSN
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9780750340038
- Classification
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616.994
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Second edition.
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- Statement of Responsibility
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Claudia Tanja Mierke.
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