The brain-bladder axis in tissue growth and remodelling /

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The brain-bladder axis in tissue growth and remodelling /

Miftahof, Roustem N., - Personal Name; Institute of Physics (Great Britain), - Personal Name; Cyron, Christian J., - Personal Name;

"Version: 20210207"--Title page verso.Includes bibliographical references.1. Anatomical and morphological preliminaries -- 1.1. Overview of the urinary bladder -- 1.2. Detrusor muscle -- 1.3. 'Pacemakers' -- 1.4. Mechanosensation -- 1.5. Afferent signalling -- 1.6. Neuronal assemblies in the hypothalamus and adenohypophysis2. Continual models of the bladder tissue -- 2.1. Single-phase models -- 2.2. Multiphase models3. Models of the urinary bladder -- 3.1. The bladder as shell structure -- 3.2. The bladder as soft bioshell4. Signalling mechanisms -- 4.1. L-Glutamate -- 4.2. GABA -- 4.3. Glycine -- 4.4. Somatostatin -- 4.5. Growth hormone releasing hormone -- 4.6. Ghrelin -- 4.7. Growth hormone -- 4.8. Insulin-like growth factor-1 -- 4.9. Myogenesis -- 4.10. Collagenesis5. Modelling the (intra)hypothalamic-pituitary axis -- 5.1. Signal transduction -- 5.2. Protein-tyrosine kinase receptor signalling -- 5.3. Gene expression -- 5.4. Hormonal interactions6. Growth and remodelling -- 6.1. Biological preliminaries -- 6.2. Continuum mechanics growth and remodelling models7. Brain-bladder axis in tissue growth and remodelling -- 7.1. The architecture of the BBA -- 7.2. Mathematical formulation of the BBA -- 7.3. An Achilles' heel -- 7.4. Simulation results8. What is to follow? -- 8.1. Making a model reliable -- 8.2. Model expansions in biomedicine -- 8.3. Implementations in engineering.Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations.Academic, Research and Industrial Scientists. The prerequisites to the book are a familiarity with the basic principles of cell and molecular biology, biochemistry and the mechanics of solids.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Prof. Dr. R.N. Miftahoft is a Professor Emeritus of applied mathematics and medicine. He is internationally acclaimed as a leading scientist in the field of computational systems biology. He has authored and co-authored seven books in the field. Prof. Dr-Ing. C.J. Cyron is a Full Professor at Hamburg University of Technology and has actively participated in the organization of a host of conferences, workshops and summer schools on biomechanics and mechanobiology over a number of years.Title from PDF title page (viewed on August 5, 2021).

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Series Title: -
Call Number: -
Publisher: : .,
Collation: 1 online resource (various pagings) :illustrations (some color).
Language: English
ISBN/ISSN: 9780750335676
Classification: 612.4/673
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): Biomedical engineering.
Models, Theoretical.
Medical physics and biophysics.
Bladder
Tissue remodeling
Neurobiology.
Urinary Bladder
Regeneration.
Specific Detail Info: -
Statement of Responsibility: Roustem N. Miftahof and Christian J. Cyron.

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