Biophysical and chemical properties of collagen :biomedical applications /

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"Version: 20191101"--Title page verso.Includes bibliographical references.part I. Introduction. 1. Introduction -- 1.1. Overviewpart II. The structure and biochemistry of collagen. 2. The structure of collagen -- 2.1. Composition -- 2.2. X-ray diffraction studies -- 2.3. Different collagen types -- 2.4. Other proteins with a triple-helix -- 2.5. Protein sequences3. Biosynthesis and biodegradation of collagen -- 3.1. Biosynthetic pathway -- 3.2. Selected secondary modification enzymes in collagen biosynthesis -- 3.3. Degradation of collagen in tissues4. Collagen assemblies -- 4.1. Ordered collagen structures -- 4.2. Fibrillogenesis5. Tissue arrangement -- 5.1. Formation of new tissue -- 5.2. Native crosslinking -- 5.3. Examples of tissue structure -- 5.4. Mineralisation -- 5.5. Mechanical properties6. Collagen stability -- 6.1. Molecular stability -- 6.2. Solvent effects on stability -- 6.3. Peptide models to study stability -- 6.4. Other uses for peptide models7. Interactions -- 7.1. Describing interactions with other molecules -- 7.2. Interactions with other collagens -- 7.3. Interactions with proteoglycans -- 7.4. Interaction with globular proteins -- 7.5. Interactions with the immune system -- 7.6. Antibodies to collagens as biochemical reagentspart III. The production of collagen-based biomaterials. 8. Production of tissue-derived collagens -- 8.1. Tissue and fibrous collagen -- 8.2. Acellular matrix -- 8.3. Soluble collagens -- 8.4. Production of collagen in cell culture -- 8.5. Fractionation of soluble collagens -- 8.6. Further purification of soluble collagens9. Production of recombinant collagens -- 9.1. Recombinant animal collagen production -- 9.2. Recombinant bacterial collagen production -- 9.3. Recombinant 'bioengineered' adaptations to collagen structures -- 9.4. Recombinant chimeric fusion proteins -- 9.5. De novo designed structures10. Evaluation of the quality of collagen preparations -- 10.1. Collagen quantitation -- 10.2. Solution properties -- 10.3. Electrophoretic methods -- 10.4. Optical methods -- 10.5. Biophysical methods11. Fabrication of biomedical products -- 11.1. Gels and hydrogels -- 11.2. Foams and sponges -- 11.3. Reconstituted fibres -- 11.4. Films and membranes -- 11.5. Beads and particles -- 11.6. Fibrous capsule materials -- 11.7. Other technologies -- 11.8. Sterilisation12. Chemical modifications -- 12.1. Chemical crosslinking methods -- 12.2. Physical crosslinking -- 12.3. Assessing the effectiveness of crosslinking -- 12.4. Site-specific chemical modificationspart IV. Applications of collagen in medical products. 13. Applications for intact tissue collagen -- 13.1. Stabilised tissues -- 13.2. Acellular matrix14. Applications for purified collagen -- 14.1. Gels and hydrogels -- 14.2. Foams and sponges -- 14.3. Films and membranes -- 14.4. Beads and particles -- 14.5. Reconstituted fibres15. Applications of biosynthetic materials -- 15.1. Vascular devices -- 15.2. Hernia, ligament and other options16. Collagen applications in tissue engineering and regenerative medicine -- 16.1. Fabricated collagen as a supporting structure -- 16.2. ACM as a supporting structure17. Coating of biomedical materials with collagen -- 17.1. Coating of synthetic polymers -- 17.2. Collagen on metals and inorganic materials18. Composites of collagen with other materials -- 18.1. Composites with other biopolymers -- 18.2. Composites with synthetic polymers -- 18.3. Composites with inorganic materials -- 18.4. Composites with bioactive entitiespart V. Conclusions. 19. Concluding remarks.Collagen has proved to be a safe and effective biomedical material. Clinicians have used collagen-based devices in a wide range of applications with successful patient outcomes. This book gives an understanding of how present devices work, and could be improved, as well as the development of new devices where a knowledge of collagen structure, chemistry and biology is required. The purification of collagen materials and the fabrication of a range of collagen products and their applications are covered within. Current developments include recombinant collagen materials that provide further application opportunities. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students. Part of Biophysical Society Series.Post-graduates and researchers.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.John Ramshaw is a chemist who studied at Van Mildert College, Durham University, UK, where he was awarded BSc, PhD and DSc degrees. He recently retired as a chief research scientist at CSIRO and is now at The University of Melbourne. He has extensive experience of collagen and biomedical materials, through research leading to papers and patents, consulting and innovation. Veronica Glattauer graduated from La Trobe University in Melbourne, Australia, with a BSc in chemistry and biochemistry. She was later awarded a PGDip in computer science from Monash University. She has extensive scientific knowledge in the area of biomaterial science and engineering, extracellular matrix biology (principally collagen), protein chemistry and cell biology.Title from PDF title page (viewed on December 9, 2019).

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Publisher

: .,

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1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9780750320962

Classification

572.67

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Subject(s)

Biophysics.
SCIENCE / Life Sciences / Biophysics.
Collagen

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John A.M. Ramshaw, Veronica Glattauer.

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