Introduction to pharmaceutical biotechnology.

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"Version: 20180901"--Title page verso.Includes bibliographical references.1. Introduction to enzymes and their applications -- 1.1. Introduction -- 1.2. Properties of enzymes -- 1.3. Catalysis -- 1.4. The structure of enzymes -- 1.5. Structural features : primary and secondary structures -- 1.6. The mechanism of action of enzymes -- 1.7. Catalysis via chymotrypsin -- 1.8. Enzyme inhibition -- 1.9. Pharmaceutical applications -- 1.10. Plants and algae enzyme systems2. Technologies and procedures involved in enzyme production -- 2.1. Introduction -- 2.2. Enzyme production technology -- 2.3. Procedures involved in enzyme production -- 2.4. Recombinant proteins from algae3. Industrial enzymes and their applications -- 3.1. Industrial enzymes -- 3.2. Bacterial gas-amylases -- 3.3. Fungal gas-amylases -- 3.4. Bacterial proteases -- 3.5. Fungal proteases -- 3.6. Glucose isomerase (D-xylose ketol-isomerase; EC. 5.3.1.5) -- 3.7. Penicillinase -- 3.8. Chloramphenicol acetyltransferase -- 3.9. Aminoglycoside antibiotic inactivating enzymes -- 3.10. Fibrinolytic enzymes -- 3.11. Biotechnological applications of enzymes4. Immobilization of enzymes -- 4.1. Introduction -- 4.2. Types of immobilization -- 4.3. Genetic engineering for microbial enzyme production -- 4.4. Protein studies for modification of commercial enzymes -- 4.5. Enzyme and cell immobilization -- 4.6. Immobilization methods -- 4.7. Choice of immobilization technique -- 4.8. Immobilization of cells -- 4.9. Manufacture of commercial products -- 4.10. Application of various immobilization techniques for algal bioprocesses5. Biosensors -- 5.1. Introduction -- 5.2. Principles of a biosensor -- 5.3. Different types of biosensors -- 5.4. Applications of biosensors6. Biotransformation and enzymes -- 6.1. Introduction -- 6.2. Types of biotransformation reactions -- 6.3. Sources of biocatalysts and techniques for biotransformation -- 6.4. Product recovery in biotransformations -- 6.5. Application of biotransformation in the production of pharmaceutical products7. Introduction to genomics -- 7.1. Introduction -- 7.2. Characterizations in genomics -- 7.3. Historical background -- 7.4. Genome sequencing -- 7.5. Understanding bioinformatics and sequencing -- 7.6. Comparative genomics as a technique to understand evolution -- 7.7. Gene estimation and counting -- 7.8. Genomes : genome evolution -- 7.9. Algae bioinformatics8. Basics of proteomics -- 8.1. Introduction -- 8.2. Types of proteomics -- 8.3. Basic techniques involved in proteomics -- 8.4. Complete proteome of Mycoplasma genitalium -- 8.5. Architecture and design of the nuclear pore complex -- 8.6. Functional genomics and systems biology -- 8.7. Synthetic genomics9. Bioinformatics -- 9.1. Introduction -- 9.2. History of bioinformatics -- 9.3. Sequences and nomenclature -- 9.4. Investigation by means of bioinformatics tools10. Protein and enzyme engineering -- 10.1. Protein and enzyme engineering -- 10.2. Designing macromolecules -- 10.3. Protein engineering versus enzyme engineering -- 10.4. Protein engineering -- 10.5. Foundation of protein (enzyme) engineering -- 10.6. Basic assumptions for protein engineering -- 10.7. Steps involved in protein engineering -- 10.8. Methods of protein engineering -- 10.9. Mutagenesis and selection of mutant enzymes -- 10.10. Gene modifications or gene synthesis for protein engineering -- 10.11. Multi-enzyme systems -- 10.12. Chemical modification of enzyme -- 10.13. Some early achievements of protein engineering.Introduction to Pharmaceutical Biotechnology, Volume 2 provides background information and knowledge on areas such as genes, enzymes and proteins. It is organized into these three important areas starting with the general properties, mechanisms, applications, production, immobilization, and purification of enzymes and ending with additional applications in biosensors and biotransformation reactions. Additionally, the book addresses the characteristics in genomics, genomes sequencing, comparative genomics, and genomic evolution. Other highlighted areas pertain to the rapidly developing area of protein engineering. Given the wide area of subjects covered, this book will be of interest to biochemists, biologists, microbiologists, biotechnologists, food technologists, and all others involved in the research and development of the biological applications of proteins and enzymes.Researchers and graduate students.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.Dr Saurabh Bhatia is an Associate Professor at Amity institute of Pharmacy Amity university. Gurgaon, Haryana in India. He has academic experience in a number of specialized areas including pharmacology, natural products science, biotechnology, and drug delivery systems. He has promoted several marine algae and their derived polymers throughout India and has published more than six books in many areas of pharmaceutical science.Title from PDF title page (viewed on October 16, 2018).

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Publisher

: .,

Collation

1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9780750313025

Classification

338.4/76153

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Subject(s)

SCIENCE / Life Sciences / Biophysics.
Pharmaceutical biotechnology.
Biopharmaceutics.
Drug Therapy
Drug Industry
Genetic Phenomena.
Genetic engineering.

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Saurabh Bhatia.

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