Evolutionary dynamics :the mathematics of genes and traits /

---

"Version: 20150701"--Title page verso.Includes bibliographical references.Preface -- Acknowledgements -- 1. Introduction -- 1.1. Of snails and snakes -- 1.2. The three key elements -- 1.3. Stochasticity -- 1.4. Towards a mathematics of evolution -- 1.5. Organization of this book2. Cell biology and molecular genetics -- 2.1. Cellular architecture and proliferation -- 2.2. DNA, RNA and proteins -- 2.3. Metabolism3. Phylogeny and development -- 3.1. Phylogenic trees -- 3.2. Development4. Elementary evolutionary dynamics -- 4.1. Conceptual challenges and the standard assumption -- 4.2. Haploids -- 4.3. Diploids -- 4.4. Projection onto tightly linked clusters of loci -- 4.5. Drift and fixation5. Probability and measurement -- 5.1. Fundamental laws of probability -- 5.2. Random variables and their distributions -- 5.3. Expectation and variance -- 5.4. Common distributions and their properties -- 5.5. Measurement scales6. Statistical inference and estimation -- 6.1. The essential ideas -- 6.2. Justifying the likelihood ratio principle -- 6.3. Linking alleles to traits -- 6.4. Microarrays: the stepping down procedure -- 6.5. Analysis of bivariate data7. Sequence, structure and function -- 7.1. Principles of dynamic programming -- 7.2. Sequence phylogenies -- 7.3. Sequence alignment -- 7.4. Deep structure -- 7.5. From sequence to function8. Analysis of quantitative trait loci -- 8.1. Recombinant distributions -- 8.2. Genetic markers and mapping -- 8.3. The number of quantitative trait loci9. Evolutionary dynamics of QTL -- 9.1. Heritability -- 9.2. Dynamics of the additive genetic component -- 9.3. The persistence of sex10. Adaptive dynamics and speciation -- 10.1. Adaptive dynamics -- 10.2. Fisher's law for adaptive dynamics -- 10.3. Adaptive radiations and mass extinctions11. Traits as objects of selection -- 11.1. Regimenting traits -- 11.2. Scope and limitations of the additive genetic model12. Fitness and optimality -- 12.1. Evolution of protandry in butterflies -- 12.2. Evolution of juvenility -- 12.3. Evolution of homeostasis -- 12.4. Fitness probesAppendices. -- A. Species, speciation and systematics -- B. Dangerous ideas -- C. Dynamics -- D. Constrained optimization -- E. Thermal physics.Written for researchers and postgraduate students with a background in physics or applied mathematics and a desire to apply their skills to problems in the life sciences, this beautifully illustrated and stimulating book develops an understanding of the gene-to-trait problem in the context of evolutionary dynamics, from the modern perspective of integrative biology. The gene-to-trait problem resides at the heart of a great many questions in biology. The author presents both elementary and advanced material in a way that brings out how this gene-to-trait problem is treated in the contexts of bioinformatics and evolutionary dynamics. Key ideas and techniques that underlie some of the most-used bioinformatics methods are discussed in an integrative context and a wide range of examples of mathematical models of living things is developed in an evolutionary framework.Advanced students in mathematics, physics and computer science taking courses or starting research in bioinformatics, systems biology and evolutionary dynamics. Established researchers in the same fields.Also available in print.Mode of access: World Wide Web.System requirements: Adobe Acrobat Reader.Hugo van den Berg is a lecturer at the University of Warwick's Mathematics Institute where he specialises in mathematical biology and teaches courses in mathematical, quantitative and system biology. His research interests include the applications of mathematical and statistical biology to the dynamics and efficacy of the cellular immune system.Title from PDF title page (viewed on July 1, 2015).

---

Availability

No copy data

Detail Information

Series Title

-

Call Number

-

Publisher

: .,

Collation

1 online resource (various pagings) :illustrations (some color).

Language

English

ISBN/ISSN

9780750310949

Classification

576.801/5118

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Evolution (Biology)
Genetics
Biophysics.
SCIENCE / Life Sciences / Biophysics.

Specific Detail Info

-

Statement of Responsibility

Hugo van den Berg.

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment