"Version: 20181001"--Title page verso.Includes bibliographical references (page 35).1. Introduction -- 2. Background -- A few definitions, the double helix, and chromatin -- The linking number -- Basics of genome organisation -- 3. Current directions -- All twisted up : supercoiling, transcription, and nucleosome assembly -- Packing it all up : the 3D spatial organisation of the nucleus -- 4. O…